<p>Tumor Targeted Curcumin Delivery by Folate-Modified MPEG-PCL Self-Assembly Micelles for Colorectal Cancer Therapy</p>

Preparation and evaluation of PCL-PEG-PCL micelles as potential nanocarriers for ocular delivery of dexamethasone

Objective(s): Micelles have been studied as nanoparticulate drug delivery systems for improving the topical ocular delivery of hydrophobic drugs. The objective of this study was to develop and characterize dexamethasone-loaded polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) micelles to improve patient compliance and enhance the ocular bioavailability of poorly water-soluble ...

A novel folate-modified self-microemulsifying drug delivery system of curcumin for colon targeting

BACKGROUND The objective of this study was to prepare, characterize, and evaluate a folate-modified self-microemulsifying drug delivery system (FSMEDDS) with the aim to improve the solubility of curcumin and its delivery to the colon, facilitating endocytosis of FSMEDDS mediated by folate receptors on colon cancer cells. METHODS Ternary phase diagrams were constructed in order to obtain the m...

Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery

The purpose of this study was to develop a novel lipid-polymer hybrid drug carrier comprised of folate (FA) modified lipid-shell and polymer-core nanoparticles (FLPNPs) for sustained, controlled, and targeted delivery of paclitaxel (PTX). The core-shell NPs consist of 1) a poly(ε-caprolactone) hydrophobic core based on self-assembly of poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolact...

Folate receptor-targeted anti-cancer agent delivery

Modified Carbohydrate Polymer Based Micelles for Cancer Targeted Drug Delivery Applications

S. S. Kesharwani, P. Muley, S. Kumar, F. El Kourati, H. Tummala South Dakota State University Purpose Micelles offer several advantages for the delivery of hydrophobic drugs including a ‘core-shell’ delivery system for drug targeting. A plethora of polymers have been investigated for micellar delivery systems. Polyethylene glycol (PEG) forms the hydrophilic part of most of these amphiphilic pol...